Реакция #70519

Уравнение реакции

Phenylmethyl 2-morpholinecarboxylate

DIPEA

acetic anhydride

→

title compound

Выход 58.5%

Phenylmethyl 4-acetyl-2-morpholinecarboxylate

Выход 58.5%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed in vacuo
2. 2
   Другоеseparated by hydrophobic frit
3. 3
   ПромывкаThe aqueous layer was washed with dichloromethane (2×10 ml) and to the combined organic phases
4. 4
   workup.ADDITIONwas added saturated sodium bicarbonate solution (20 ml)
5. 5
   ДругоеThe phases were separated by hydrophobic frit
6. 6
   Промывкаthe aqueous layer was washed with dichloromethane (2×10 ml)
7. 7
   ДругоеThe solvent was removed in vacuo
8. 8
   workup.DISSOLUTIONthe residue was dissolved in dichloromethane (˜5 ml)
9. 9
   Другоеthe residue was purified by flash chromatography (
10. 10
    Промывка20 g silica, gradient elution, 0-100% EtOAc-Cyclohexane
11. 11
    ДругоеThe solvent was removed in vacuo

Методика

Phenylmethyl 2-morpholinecarboxylate (450 mg, 2.034 mmol) was dissolved in dichloromethane (30 ml). DIPEA (0.71 ml, 4.07 mmol) and acetic anhydride (0.23 ml, 2.441 mmol) were added and the mixture was stirred under nitrogen at room temperature for 18 hr. The solvent was removed in vacuo, the residue was portioned between dichloromethane (20 ml) and water (20 ml) and separated by hydrophobic frit. The aqueous layer was washed with dichloromethane (2×10 ml) and to the combined organic phases was added saturated sodium bicarbonate solution (20 ml). The phases were separated by hydrophobic frit and the aqueous layer was washed with dichloromethane (2×10 ml). The solvent was removed in vacuo, the residue was dissolved in dichloromethane (˜5 ml) and the residue was purified by flash chromatography (20 g silica, gradient elution, 0-100% EtOAc-Cyclohexane then 0-20% MeOH). The solvent was removed in vacuo to give the title compound (313 mg, 1.19 mmol) as a colourless oil.

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