Реакция #70426

Уравнение реакции

tert-butyl 4-[2-(4-ethoxycarbonyl-3-fluorophenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate

lithium hydroxide monohydrate

hydrochloric acid

→

title compound

Выход 101.1%

tert-Butyl 4-[2-(4-carboxy-3-fluorophenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate

Выход 101.1%

Растворители

ethanol

water

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted with chloroform
2. 2
   ПромывкаThe organic layer was washed with brine
3. 3
   Сушкаdried over anhydrous sodium sulfate
4. 4
   Концентрированиеconcentrated under reduced pressure

Методика

To a solution of tert-butyl 4-[2-(4-ethoxycarbonyl-3-fluorophenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate (Example 9) (60 mg, 0.131 mmol) in ethanol (0.9 mL)-water (0.2 mL) was added lithium hydroxide monohydrate (16 mg, 0.393 mmol). The mixture was stirred at room temperature overnight, diluted with water, neutralized by the addition of 1N hydrochloric acid and then extracted with chloroform. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound as a white crystal (57 mg, quantitative yield).

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