Реакция #70330

ord-3b57758fd6614679a9a60fa13dd81082

Уравнение реакции

Brc1cnc(I)nc1
5-bromo-2-iodopyrimidine
OB(O)c1ccccc1C(F)(F)F
2-(trifluoromethyl)phenylboronic acid
→
FC(F)(F)c1ccccc1-c1ncc(Br)cn1
5-bromo-2-(2-(trifluoromethyl)phenyl)pyrimidine
Выход 52.0%

Реактанты

—
Intermediate 21
Brc1cnc(I)nc1
5-bromo-2-iodopyrimidine
OB(O)c1ccccc1C(F)(F)F
2-(trifluoromethyl)phenylboronic acid

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеObtained (52% yield)

Методика

Obtained (52% yield) following the procedure described in Intermediate 21, starting with 5-bromo-2-iodopyrimidine and 2-(trifluoromethyl)phenylboronic acid.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08536165B2uspto-grants-2013_09