Реакция #7015

Уравнение реакции

amine

[4-Benzyl-5-(3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-4H-[1,2,4]triazol-3-ylmethyl]-(2-methoxy-ethyl)-amine

formaldehyde

sodium triacetoxyborohydride

→

title compound

[4-Benzyl-5-(3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-4H-[1,2,4]triazol-3-ylmethyl]-(2-methoxy-ethyl)-methyl-amine

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe reaction mixture was partitioned between dichloromethane and aqueous sodium carbonate solution
2. 2
   Другоеthe layers separated
3. 3
   СушкаThe organic phase was dried (MgSO4)
4. 4
   Другоеevaporated under reduced pressure
5. 5
   Другоеthe product triturated from ether

Методика

The amine from example 43 (50 mg, 0.12 mmol), formaldehyde (37% aq, 40 μl, 0.49 mmol) and sodium triacetoxyborohydride (51 mg, 0.24 mmol) in dichloromethane (1 ml) was stirred vigorously at room temperature for 21 hours. The reaction mixture was partitioned between dichloromethane and aqueous sodium carbonate solution, and the layers separated. The organic phase was dried (MgSO4), evaporated under reduced pressure, and the product triturated from ether to afford the title compound as a white solid.

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