Реакция #6999

Уравнение реакции

2-methoxyphenol

N,N-dimethylaniline

phosgene

DMF

→

2-methoxyphenyl chloroformate

Выход 50.0%

Растворители

toluene

chlorobenzene

Условия реакции

Обработка

1. 1
   ДругоеThe organic layer was separated
2. 2
   Концентрированиеconcentrated in vacuo
3. 3
   workup.DISTILLATIONThe residue was distilled (Buchi Kugelrohr; bp=115° C. @ 10 mm Hg)

Методика

A solution of 2-methoxyphenol (2 g, 16.1 mmol), N,N-dimethylaniline (1.95 g, 16.1 mmol), phosgene (8.34 mL of a 1.93 M solution in toluene, 16.1 mmol) and a catalytic amount of DMF in chlorobenzene (5 mL) was stirred in a pressure tube for 2 h at 80° C. The organic layer was separated and concentrated in vacuo. The residue was distilled (Buchi Kugelrohr; bp=115° C. @ 10 mm Hg) to provide 2-methoxyphenyl chloroformate (1.5g; 50%) as a clear oil.

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