Реакция #69981

Уравнение реакции

4-(4-bromophenyl)piperidin-4-ol

triethylamine

methanesulphonyl chloride

→

4-(4-bromophenyl)-1-(methanesulphonyl)piperidin-4-ol

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ПромывкаIt is washed with water
2. 2
   СушкаThe organic phase is dried over sodium sulphate
3. 3
   Другоеevaporated under reduced pressure
4. 4
   ДругоеThe crude product obtained
5. 5
   Другоеis chromatographed on silica gel, elution

Методика

1 g of 4-(4-bromophenyl)piperidin-4-ol is placed in 20 ml of dichloromethane. 0.65 ml of triethylamine and then 0.33 ml of methanesulphonyl chloride are added. The reaction mixture is stirred at ambient temperature for 2 h. It is washed with water and then with a saturated aqueous sodium chloride solution. The organic phase is dried over sodium sulphate and then evaporated under reduced pressure. The crude product obtained is chromatographed on silica gel, elution being carried out with a dichloromethane/methanol (99/1) solvent mixture. 1.1 g of 4-(4-bromophenyl)-1-(methanesulphonyl)piperidin-4-ol are obtained.

Источник