Реакция #698778

Уравнение реакции

ethyl bromopyruvate

2-imino-4-thiobiuret

→

ethyl 2-guanidino-thiazole-4-carboxylate hydrobromide

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураthe reaction mixture is heated
2. 2
   Температураunder reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991))
3. 3
   Другоеthe reaction product is precipitated by the addition of 550 ml of ethyl acetate
4. 4
   Фильтрацияfiltered off

Методика

13.9 ml of ethyl bromopyruvate are added to a solution of 11.81 g of 2-imino-4-thiobiuret (Aldrich) in 100 ml of ethanol and the reaction mixture is heated under reflux for 3 hours (J. Med. Chem. 34, 914-918 (1991)). Subsequently, the mixture is cooled to room temperature and the reaction product is precipitated by the addition of 550 ml of ethyl acetate and filtered off. There are obtained 14.6 g of yellowish ethyl 2-guanidino-thiazole-4-carboxylate hydrobromide. MS: 214 (M)+.

Источник