Реакция #6977

Уравнение реакции

sodium ethoxide

ethyl-6-amino-nicotinate

benzoyl isothiocyanate

→

6-thioureido-nicotinic acid ethyl ester

Выход 77.0%

Растворители

ethanol

THF

Условия реакции

Обработка

1. 1
   Другоеthe volatiles were removed in vacuo
2. 2
   Другоеthe solid formed
3. 3
   Фильтрацияwas collected by filtration
4. 4
   Промывкаrinsed with water
5. 5
   Другоеdried

Методика

A mixture of ethyl-6-amino-nicotinate (2.5 g, 15 mmol) and benzoyl isothiocyanate (2.45 g, 15 mmol) in THF (20 mL) was heated at 40° C. for 4 h. To this mixture at RT, was added sodium ethoxide (2.04 g, 30 mmol) in ethanol (10 mL). After stirring the resulting mixture at RT for 16 h, the volatiles were removed in vacuo. The residue was suspended in aqueous NH4Cl and the solid formed was collected by filtration, rinsed with water and dried to afford 6-thioureido-nicotinic acid ethyl ester as a white solid (2.6 g, 77% yield). LC/MS; (M+H)+=226.

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