Реакция #696703

Уравнение реакции

4-Vinylbenzyl chloride

Ethyl acetoacetate

sodium ethoxide

→

ethyl 2-(4-vinylbenzyl)-3-oxobutanoate

Выход 95.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураwas cooled in an ice-water bath
2. 2
   ТемператураThe mixture was refluxed for 16 hours
3. 3
   Фильтрацияthe resulting slurry was filtered
4. 4
   Другоеto remove any salt
5. 5
   Другоеthe solution collected
6. 6
   ДругоеThe solvent was removed under reduced pressure

Методика

Ethyl acetoacetate (27.61 g, 0.21 mol) was dissolved in ethanol (100 ml) which was cooled in an ice-water bath, and sodium ethoxide (15.59 g, 0.22 mol) was added. 4-Vinylbenzyl chloride (33.92 g, 0.2 mole) was added. The mixture was refluxed for 16 hours, then the resulting slurry was filtered to remove any salt, and the solution collected. The solvent was removed under reduced pressure to give ethyl 2-(4-vinylbenzyl)-3-oxobutanoate in the form of a light red liquid (49 g) in 95% yield.

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