Реакция #6945

Уравнение реакции

4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile

DMF-DMA

→

desired product

4-(3-Dimethylamino-acryloyl)-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураthe resulting mixture heated
2. 2
   Температураat reflux for 18 hours
3. 3
   КонцентрированиеThe reaction was concentrated
4. 4
   Другоеthe residue triturated with diethyl ether (20 mL)
5. 5
   ФильтрацияThe suspension was filtered
6. 6
   Промывкаwashed with ether

Методика

To a solution of 4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile (10 mmol) in acetonitrile (5 mL) was added DMF-DMA (2 mL) and the resulting mixture heated at reflux for 18 hours. The reaction was concentrated and the residue triturated with diethyl ether (20 mL). The suspension was filtered and washed with ether to afford the desired product as a yellow solid.

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