Реакция #692615

Уравнение реакции

4-Hydroxybutan-2-one

imidazole

tert-butyldimethylsilyl chloride

→

title compound

Выход 94.0%

4-(tert-butyldimethylsilyloxy)butan-2-one

Выход 94.0%

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеThe reaction was partitioned with ether and water
2. 2
   ЭкстракцияThe aqueous phase was extracted several times with ether
3. 3
   ПромывкаThe combined organics were washed several times with water
4. 4
   Сушкаthen dried over magnesium sulfate
5. 5
   Концентрированиеconcentrated in vacuo

Методика

4-Hydroxybutan-2-one (1.0 g, 11.35 mmol), imidazole (1.16 g, 17 mmol) in DMF (15 ml) was reacted with tert-butyldimethylsilyl chloride (1.7 g, 11.35 mmol) for three hours at room temperature. The reaction was partitioned with ether and water. The aqueous phase was extracted several times with ether. The combined organics were washed several times with water then dried over magnesium sulfate and concentrated in vacuo to give the title compound as a clear oil (2.16 g, 94%).

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