Реакция #6920

Уравнение реакции

2-Bromothiazole-4-carbaldehyde

ethylene glycol

→

product

Выход 74.7%

2-Bromo-4-(1,3-dioxolan-2-yl) thiazole

Выход 74.7%

Растворители

toluene

Условия реакции

Обработка

1. 1
   Другоеfitted, for 18 hr
2. 2
   КонцентрированиеThe product was concentrated
3. 3
   Другоеpurified by column chromatography (15% ethyl acetate /hexane)

Методика

2-Bromothiazole-4-carbaldehyde (6.56 g, 34.17 mmol) [A. T. Ung, S. G. Pyne/Tetrahedron: Asymmetry 9 (1998) 1395–1407] and ethylene glycol (5.72 ml, 102.5 mmol) were heated under reflux in toluene (50 ml), with a Dean and Stark trap fitted, for 18 hr. The product was concentrated and purified by column chromatography (15% ethyl acetate /hexane) to give the product as a yellow solid (6.03 g); m/z 236,238.

Источник