Реакция #691569

Уравнение реакции

piperidine

Hydroxyacetophenone

K2CO3

α,α′-dibromoxylol

→

α-(4-Acetylphenoxy)-α′-piperidino p-xylol

Растворители

acetone

DMF

Условия реакции

Обработка

1. 1
   Температураunder reflux
2. 2
   ДругоеThe solvent was evaporated under reduced pressure
3. 3
   Экстракцияextracted with methylene chloride
4. 4
   ДругоеThe combined organic extracts were crystallized with oxalic acid
5. 5
   ДругоеRecrystallization
6. 6
   Другоеresulted in the pure product

Методика

Hydroxyacetophenone (2 mmol) and 5 mmol of K2CO3 were stirred in 20 ml of acetone with 2 ml of DMF for 10 minutes. After addition of 3.5 mmol of α,α′-dibromoxylol the reaction was stirred at ambient temperature for 12 hours and after addition of 7 mmol of piperidine for 1 hour under reflux. The solvent was evaporated under reduced pressure. The residue was suspended in water, extracted with methylene chloride. The combined organic extracts were crystallized with oxalic acid. Recrystallization resulted in the pure product.

Источник