Реакция #69128

Уравнение реакции

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate

→

title compound

Выход 61.0%

(R)-tert-butyl 1-(4-hydroxycyclohexyl)ethylcarbamate

Выход 61.0%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe rhodium catalyst was filtered off
2. 2
   Концентрированиеthe mother liquors were concentrated in vacuo
3. 3
   ДругоеThe residue was purified on silica gel by flash column chromatography

Методика

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate (described in the literature: WO 2007035154 (A1)) (100 mg, 0.4214 mmol) was dissolved in methanol (5 mL). A methanolic (5 mL) solution of rhodium on alumina (10 Wt %, 10 mg) was added. The reaction mixture was place under a hydrogen atmosphere and stir at room temperature for 18 hours. The rhodium catalyst was filtered off and the mother liquors were concentrated in vacuo. The residue was purified on silica gel by flash column chromatography to afford the title compound (62 mg, 61% yield).

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