Реакция #6889

Уравнение реакции

1-(3,5-bistrifluoromethylphenyl)-3-bromoprop-1-yne

piperidine

potassium carbonate

→

oil

1-[3-(3,5-Bistrifluoromethylphenyl)-2-propynyl]piperidine

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураat reflux
3. 3
   ДругоеRemoval of the solvent
4. 4
   workup.DISTILLATIONunder reduced pressure and distillation of the residue under reduced pressure

Методика

A mixture of 1-(3,5-bistrifluoromethylphenyl)-3-bromoprop-1-yne (2.53 g), piperidine (5 ml) and anhydrous potassium carbonate (5 g) in dry acetone (50 ml) was heated at reflux with stirring for 18 h. Removal of the solvent under reduced pressure and distillation of the residue under reduced pressure gave 2.26 g of an oil of boiling point 95° C./0.025 mm Hg.

Источник