Реакция #6886

Уравнение реакции

3-fluoroiodobenzene

4-methyl-1-(2-propynyl)piperidine

→

oil

Выход 56.2%

1-[3-(3-Fluorophenyl)-2-propynyl]-4-methylpiperidine

Выход 56.2%

Растворители

diethylamine

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураunder reflux for 5 hours
3. 3
   ДругоеThe solvent was removed under reduced pressure
4. 4
   Промывкаwashed with water
5. 5
   СушкаThe organic phase was dried over magnesium sulfate
6. 6
   Другоеthe solvent was removed under reduced pressure
7. 7
   workup.DISTILLATIONDistillation of the residue under reduced pressure

Методика

A mixture of 3-fluoroiodobenzene (8.88 g), 4-methyl-1-(2-propynyl)piperidine (6.80 g), palladium acetate (0.045 g), tri-o-toloylphosphine (0.24 g) and copper(I) iodide (0.1 g) in dry diethylamine (50 ml) was heated under reflux for 5 hours. The solvent was removed under reduced pressure and the residue was taken up in diethyl ether and washed with water. The organic phase was dried over magnesium sulfate and the solvent was removed under reduced pressure. Distillation of the residue under reduced pressure gave an oil (5.20 g) of boiling point 105° C./0.07 mm Hg.

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