Реакция #68849

Уравнение реакции

1-bromomethyl-2,2-difluorocyclopropane

K2CO3

2-chloro-5-hydroxypyrimidine

→

2-Chloro-5-((2,2-difluorocyclopropyl)methoxy)pyrimidine

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеThen the reaction mixture is quenched by the addition of water
2. 2
   Экстракцияextracted with DCM
3. 3
   СушкаThe organic layer is dried with Na2SO4
4. 4
   Другоеthe solvent is removed in vacuo
5. 5
   ДругоеThe residue is purified by HPLC (MeOH/H2O/NH3)

Методика

295 mg (1.72 mmol) 1-bromomethyl-2,2-difluorocyclopropane and 318 mg (2.30 mmol) K2CO3 are added to a mixture of 150 mg (1.15 mmol) 2-chloro-5-hydroxypyrimidine in 2 mL DMF. The mixture is stirred at 80° C. over night. Then the reaction mixture is quenched by the addition of water and extracted with DCM. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo. The residue is purified by HPLC (MeOH/H2O/NH3).

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