Реакция #68766

ord-9dce468465bd408db8044e09cd781334

Уравнение реакции

O=c1[nH]c2ccccc2s1
3H-benzothiazol-2-one
CC(C)(C)C(=O)OCI
iodomethyl pivalate
CC#CC(CC(=O)OC)c1ccc(O)cc1
methyl 3-(4-hydroxyphenyl)hex-4-ynoate
→
CC#CC(CC(=O)O)c1ccc(OCn2c(=O)sc3ccccc32)cc1
3-[4-(2-oxobenzothiazol-3-ylmethoxy)-phenyl]hex-4-ynoic acid

Реактанты

O=c1[nH]c2ccccc2s1
3H-benzothiazol-2-one
CC(C)(C)C(=O)OCI
iodomethyl pivalate
CC#CC(CC(=O)OC)c1ccc(O)cc1
methyl 3-(4-hydroxyphenyl)hex-4-ynoate

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

Analogously to example 6, 3H-benzothiazol-2-one, iodomethyl pivalate and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-[4-(2-oxobenzothiazol-3-ylmethoxy)-phenyl]hex-4-ynoic acid.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08530413B2uspto-grants-2013_09