Реакция #68747

Уравнение реакции

2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone

→

2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione

Растворители

acetone

hydrochloric acid

water

hydrochloric acid

Условия реакции

Обработка

1. 1
   Экстракцияthe crude product is extracted with ethyl acetate (3×15 ml)
2. 2
   Промывкаwashed with brine (10 ml)
3. 3
   Сушкаdried over anhydrous magnesium sulfate
4. 4
   Фильтрацияfiltered
5. 5
   Другоеthe filtrate is evaporated to dryness under reduced pressure

Методика

A solution of 2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone (200 mg, 0.61 mmol) in acetone (4 ml) and 2M aqueous hydrochloric acid (4 ml) is heated at 120° C. for 20 minutes under microwave irradiation. The reaction mixture is diluted with water (20 ml) and 2M aqueous hydrochloric acid (10 ml), and the crude product is extracted with ethyl acetate (3×15 ml). The organic extracts are combined, washed with brine (10 ml), dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated to dryness under reduced pressure to give 2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione.

Источник