Реакция #684984

Уравнение реакции

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-pyrazole-3-carboxylic acid

ethanol

p-toluenesulfonic acid monohydrate

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title compound

5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4,5-dihydro-1H-pyrazol-3-carboxylic acid ethyl ester

Растворители

toluene

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling to room temperature
2. 2
   Промывкаthe reaction mixture washed with sodium hydrogen carbonate solution and water
3. 3
   Сушкаdried over sodium sulphate
4. 4
   Другоеevaporated to dryness

Методика

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-pyrazole-3-carboxylic acid (0.55 g, 1.50 mmol) was dissolved in 20 mL of toluene and (2 mL) ethanol and (0.05 g) of p-toluenesulfonic acid monohydrate were added. The mixture was heated at 80° C. for 72 hours. After cooling to room temperature, the reaction mixture washed with sodium hydrogen carbonate solution and water, dried over sodium sulphate and evaporated to dryness to give the title compound in form of oil.

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