Реакция #684981

Уравнение реакции

Trifluoroacetic acid

(4-(dodecanoylsulfamoyl)benzyl)carbamic acid tert-butyl ester

→

trifluoroacetic salt

Выход 128.9%

4-Aminomethyl-N-(dodecanoyl)benzenesulfonamide

Выход 128.9%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеwas at room temperature
2. 2
   ДругоеThe solvents were removed in vacuo
3. 3
   workup.DISSOLUTIONThe residue was dissolved in dichloromethane (40 ml)
4. 4
   Другоеthe solvent was removed in vacuo

Методика

Trifluoroacetic acid (25 ml) was at room temperature added to a solution of (4-(dodecanoylsulfamoyl)benzyl)carbamic acid tert-butyl ester (170 mg, 0.40 mmol) in dichloromethane (25 ml). The reaction mixture was stirred for 1 h at room temperature. The solvents were removed in vacuo. The residue was dissolved in dichloromethane (40 ml) and the solvent was removed in vacuo. The latter procedure was repeated once to give 0.19 g of the trifluoroacetic salt of 4-aminomethyl-N-(dodecanoyl)benzenesulfonamide.

Источник