Реакция #684975

Уравнение реакции

ethyl acetate

Potassium carbonate

methyl iodide

compound

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

→

title compound

Выход 84.4%

2-(4-Bromo-2-fluorobenzyl)-3-methoxypyridine

Выход 84.4%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   Промывкаthe reaction mixture was washed with saturated brine
2. 2
   Концентрированиеconcentrated under reduced pressure
3. 3
   ДругоеThe residue was purified by silica gel column chromatography

Методика

Potassium carbonate (38.7 mg, 0.280 mmol) and methyl iodide (10.5 μl, 0.168 mmol) were added to a solution of the compound of Example B245 (15.8 mg, 0.0560 mmol) in dimethylformamide (1 ml), and this reaction mixture was stirred at room temperature for 2 hours. After ethyl acetate was added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (14.0 mg).

Источник