Реакция #684974

Уравнение реакции

ethyl acetate

Trifluoroacetic acid

compound

2-(4-Bromo-2-fluorobenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

→

title compound

Выход 84.1%

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

Выход 84.1%

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   ПромывкаThe ethyl acetate layer was washed with saturated brine
3. 3
   Концентрированиеconcentrated under reduced pressure
4. 4
   ДругоеThe residue was purified by silica gel column chromatography

Методика

Trifluoroacetic acid (1 ml) was added to the compound of Example B244 (134 mg, 0.411 mmol) in methylene chloride (4 ml), and this reaction mixture was stirred at room temperature overnight. After neutralizing the mixture with saturated aqueous sodium hydrogencarbonate, ethyl acetate was added. The ethyl acetate layer was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (97.5 mg).

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