Реакция #684971

Уравнение реакции

Trifluoroacetic acid

compound

2-(4-Butylbenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

ethyl acetate

→

title compound

Выход 88.8%

2-(4-Butylbenzyl)-3-pyridinol

Выход 88.8%

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   Промывкаthe reaction mixture was washed with saturated brine
2. 2
   Концентрированиеconcentrated under reduced pressure
3. 3
   ДругоеThe residue was purified by silica gel column chromatography

Методика

Trifluoroacetic acid (1 ml) was added to a solution of the compound of Example B229 (256 mg, 0.849 mmol) in methylene chloride (5 ml), and this reaction mixture was stirred at room temperature overnight. After a saturated aqueous sodium hydrogencarbonate solution and ethyl acetate were added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (182 mg).

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