Реакция #684970

Уравнение реакции

Potassium carbonate

methyl iodide

compound

1-(4-Bromo-2-hydroxyphenyl)-1-butanone

→

title compound

Выход 67.7%

1-(4-Bromo-2-methoxyphenyl)-1-butanone

Выход 67.7%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураwhile heating
2. 2
   Температураunder reflux for 4 hours
3. 3
   ФильтрацияThe reaction mixture was filtered through celite, ether
4. 4
   workup.ADDITIONwas added
5. 5
   Другоеto remove insoluble material
6. 6
   Фильтрацияby filtration
7. 7
   Концентрированиеthe filtrate was concentrated under reduced pressure
8. 8
   ДругоеThe residue was purified by silica gel column chromatography

Методика

Potassium carbonate (9.07 g) and methyl iodide (3.92 ml) were added to a solution of the compound of Example B220 (13.30 g) in acetone (75 ml), and this reaction mixture was stirred while heating under reflux for 4 hours. The reaction mixture was filtered through celite, ether was added to remove insoluble material by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (9.52 g).

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