Реакция #684969

Уравнение реакции

Water

ethyl acetate

1-hydroxyisoquinoline

Bromine

→

title compound

Выход 80.1%

4-Bromo-1-isoquinolinol

Выход 80.1%

Растворители

tetrahydrofuran

acetic acid

Условия реакции

Обработка

1. 1
   Другоеthe resulting reaction mixture
2. 2
   Фильтрацияwas filtered
3. 3
   Фильтрацияthrough filter paper
4. 4
   ПромывкаThe organic layer was washed with saturated brine
5. 5
   Концентрированиеconcentrated under reduced pressure
6. 6
   ДругоеThe residue was recrystallized from ethyl acetate and hexane

Методика

Bromine (1.78 ml, 34.5 mmol) was added to an ice-cooled solution of 1-hydroxyisoquinoline (5.01 g, 34.5 mmol) in acetic acid (50 ml), and this reaction mixture was stirred at room temperature for 2 hours. Water, ethyl acetate, and tetrahydrofuran were added, and the resulting reaction mixture was filtered through filter paper. The organic layer was washed with saturated brine and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate and hexane to give the title compound (6.19 g).

Источник