Реакция #684965

Уравнение реакции

hydrobromic acid

compound

1-(4-Butylbenzyl)-6-methoxyisoquinoline

→

title compound

Выход 94.6%

1-(4-Butylbenzyl)-6-isoquinolinol

Выход 94.6%

Условия реакции

Обработка

1. 1
   Температураunder reflux for 19 hours
2. 2
   КонцентрированиеThe mixture was concentrated under reduced pressure, water
3. 3
   workup.ADDITIONwas added
4. 4
   Другоеto precipitate crystals
5. 5
   ФильтрацияThe obtained crystals were collected by filtration
6. 6
   Промывкаwashed with water
7. 7
   Другоеdried

Методика

A 47% hydrobromic acid solution was added to the compound of Example B146 (82 mg), and the mixture was stirred under reflux for 19 hours. The mixture was concentrated under reduced pressure, water was added, and the resulting mixture was neutralized with sodium carbonate to precipitate crystals. The obtained crystals were collected by filtration, washed with water, and then dried to give the title compound (74 mg).

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