Реакция #684964

Уравнение реакции

Phosphorus oxychloride

compound

N-[2-Hydroxy-2-(3-methoxyphenyl)ethyl]-2-(4-butylphenyl)-acetamide

sodium hydrogencarbonate

→

title compound

Выход 15.8%

1-(4-Butylbenzyl)-6-methoxyisoquinoline

Выход 15.8%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураunder reflux for 1 hour 30 minutes
2. 2
   ТемператураThe mixture was cooled on ice
3. 3
   Экстракцияextracted with ethyl acetate
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   Концентрированиеconcentrated under reduced pressure
6. 6
   ДругоеThe residue was purified by silica gel column chromatography

Методика

Phosphorus oxychloride (1.6 ml) was added to a solution of the compound of Example B145 (600 mg, 1.7 mmol) in acetonitrile (15 ml), and the mixture was stirred under reflux for 1 hour 30 minutes. The mixture was cooled on ice, made alkaline with a 5% aqueous sodium hydrogencarbonate solution, extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (82 mg).

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