Реакция #684962

Уравнение реакции

ammonium formate

compound

1-(3-Methoxyphenyl)-2-nitro-1-ethanol

→

title compound

Выход 72.6%

2-Amino-1-(3-methoxyphenyl)-1-ethanol

Выход 72.6%

Растворители

tetrahydrofuran

methanol

Условия реакции

Обработка

1. 1
   ДругоеThe catalyst was removed by filtration
2. 2
   workup.ADDITIONthe filtrate was diluted with ether
3. 3
   Другоеprecipitates
4. 4
   Другоеwere removed by filtration
5. 5
   Концентрированиеthe obtained filtrate was concentrated

Методика

Palladium-carbon (10%, 0.64 g) and ammonium formate (4.8 g) were added to a mixed solution of the compound of Example B142 (3.0 g, 15 mmol) in tetrahydrofuran (43 ml) and methanol (43 ml), and this mixture was stirred at room temperature for 18 hours. The catalyst was removed by filtration, the filtrate was diluted with ether, precipitates were removed by filtration, and the obtained filtrate was concentrated to give the title compound (1.82 g). This compound was used in the following reaction without further purification.

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