Реакция #684953

Уравнение реакции

ethynylbenzene

pyrrolidine

pyrrolidine

→

title compound

1-[2-(2-Phenyl-1-ethynyl)benzyl]isoquinoline

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was cooled to room temperature
2. 2
   Промывкаwashed with a saturated aqueous ammonium chloride solution
3. 3
   Сушкаdried over anhydrous magnesium sulfate
4. 4
   Концентрированиеconcentrated under reduced pressure
5. 5
   ДругоеThe residue was purified by silica gel chromatography

Методика

A solution of tetrakis(triphenylphosphine)palladium (58 mg, 0.05 mmol) and ethynylbenzene (204 mg, 2.0 mmol) in pyrrolidine (1.5 ml) was added to a solution of the compound of Example B25 (345 mg, 1.07 mmol) in pyrrolidine (1.5 ml) under nitrogen atmosphere, and the mixture was stirred at 80° C. for 3 hours. The mixture was cooled to room temperature, diluted with ethyl acetate, washed with a saturated aqueous ammonium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel chromatography to give the title compound (280 mg).

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