Реакция #684952

Уравнение реакции

sodium hydrogencarbonate

Methanesulfonyl chloride

triethylamine

o-iodobenzyl alcohol

→

title compound

Выход 100.7%

1-(Chloromethyl)-2-iodobenzene

Выход 100.7%

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   Экстракцияthe resulting mixture was extracted with methylene chloride
2. 2
   СушкаThe methylene chloride layer was dried over anhydrous magnesium sulfate
3. 3
   Концентрированиеconcentrated under reduced pressure

Методика

Methanesulfonyl chloride (2.0 ml, 29 mmol) and triethylamine (3.6 ml, 26 mmol) were added to a solution of o-iodobenzyl alcohol (5.0 g, 21 mmol) in methylene chloride (50 ml) cooled to 0° C., and the mixture was stirred at that temperature for 19 hours. A 5% aqueous sodium hydrogencarbonate solution was added, and the resulting mixture was extracted with methylene chloride. The methylene chloride layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound (5.34 g).

Источник