Реакция #684950

Уравнение реакции

compound

(4-Butylphenyl)(1-isoquinolyl)ketone

hydrazine monohydrate

potassium hydroxide

→

title compound

Выход 55.3%

1-(4-Butylbenzyl)Isoquinoline

Выход 55.3%

Растворители

diethylene glycol

Условия реакции

Обработка

1. 1
   workup.WAITat 200° C. for 1 hour
2. 2
   ТемператураThe mixture was cooled to room temperature
3. 3
   Экстракцияthis was extracted with ethyl acetate
4. 4
   ПромывкаThe extract was washed with water
5. 5
   Сушкаdried over anhydrous magnesium sulfate
6. 6
   Концентрированиеconcentrated under reduced pressure
7. 7
   ДругоеThe residue was purified by silica gel column chromatography

Методика

The compound of Example B3 (1.7 g, 6.0 mmol), hydrazine monohydrate (836 mg, 17 mmol), and potassium hydroxide (769 mg, 14 mmol) were added to diethylene glycol (8.5 ml), and this mixture was stirred at 80° C. for 1 hour, at 160° C. for 3.5 hours, then at 200° C. for 1 hour. The mixture was cooled to room temperature, ice water was added, and this was extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (914 mg).

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