Реакция #684944

Уравнение реакции

2,5-Dibromohydroquinone

sodium hydroxide

dodecylbromide

→

2,5-Dibromo-4-dodecyloxy phenol

Выход 60.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураthe reaction mixture was cooled
2. 2
   Другоеthe precipitate formed
3. 3
   Фильтрацияwas filtered
4. 4
   Промывкаwashed with methanol
5. 5
   ДругоеThe filtrate was evaporated
6. 6
   Другоеto remove the solvent
7. 7
   workup.ADDITION2 L of distilled water was added to the residue
8. 8
   workup.WAITboiled gently for 1 h
9. 9
   Температураcooled
10. 10
    ФильтрацияThe resulting precipitate was collected by filtration
11. 11
    Промывкаwashed with water
12. 12
    Другоеdried in vacuo
13. 13
    ДругоеThe crude product was purified by column chromatography
14. 14
    workup.ADDITIONa mixture of solvents (CH2Cl2:hexanes, 4:6)
15. 15
    Другоеto get the pure product in 60% yield

Методика

2,5-Dibromohydroquinone 3 (40.2 g, 0.15 mol) was dissolved in a solution of sodium hydroxide (9.2 g, 0.23 mol) in 1.5 L of absolute ethanol at room temperature under nitrogen atmosphere. The reaction mixture was warmed to 50-60° C. with constant stirring. The dodecylbromide (36 ml, 0.15 mol) was added drop wise to the above reaction mixture at 60° C. After 10 h of stirring under nitrogen atmosphere, the reaction mixture was cooled and the precipitate formed was filtered and washed with methanol. This precipitate was identified as dialleylated-2,5-dibromohydroquinone as a side product. The filtrate was evaporated to remove the solvent. 2 L of distilled water was added to the residue and the mixture was acidified with 36% HCl, boiled gently for 1 h and cooled. The resulting precipitate was collected by filtration, washed with water and dried in vacuo. The crude product was purified by column chromatography using a mixture of solvents (CH2Cl2:hexanes, 4:6) to get the pure product in 60% yield.

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