Реакция #684280

Уравнение реакции

3-nitro-phenol

potassium hydroxide

trifluoro-chloroethylene

→

3-(1',1',2'-trifluoro-2'-chloroethoxy)-aniline

Растворители

dimethyl formamide

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONThe main amount of dimethyl formamide was distilled off in vacuo
2. 2
   workup.ADDITIONThe residue was poured into ice water
3. 3
   Другоеseparated
4. 4
   Сушкаdried over Na2SO4
5. 5
   workup.DISTILLATIONdistilled in vacuo

Методика

139 grams (1 mole) of 3-nitro-phenol and 28 grams (0.5 mole) of potassium hydroxide were dissolved in 400 milliliters of dimethyl formamide, and 140 grams (1.2 mole) of trifluoro-chloroethylene were introduced in a gas pipe at 40° C; the mixture was then maintained at 60° C for 2 hours. The main amount of dimethyl formamide was distilled off in vacuo. The residue was poured into ice water, separated, dried over Na2SO4 and distilled in vacuo.

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