Реакция #68340

Уравнение реакции

ethyl3-formyl-2-isopropyl-1H-indole-6-carboxylate

Compound 34

ethyl3-formyl-2-isopropyl-1H-indole-6-carboxylate

K2CO3

2-(bromomethyl)pyridine

→

title compound

Ethyl 3-Formyl-2-isopropyl-1-(pyridin-2-ylmethyl)-1H-indole-6-carboxylate

Растворители

EtOAc

DMF

Условия реакции

Обработка

1. 1
   Промывкаwashed with H2O, brine
2. 2
   Сушкаdried over Na2SO4
3. 3
   Концентрированиеconcentrated in vacuo
4. 4
   ДругоеThe residue was purified by chromatography on silica gel (0→35% EtOAc-hexanes)

Методика

Following General Procedure C, ethyl3-formyl-2-isopropyl-1H-indole-6-carboxylate (Compound 34, 278 mg, 1.07 mmol) in DMF (15 ml) was added K2CO3 (590 mg, 4.28 mmol) and 2-(bromomethyl)pyridine (914 mg, 5.35 mmol). The reaction was stirred at 60° C. for 5 h, diluted with EtOAc, washed with H2O, brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by chromatography on silica gel (0→35% EtOAc-hexanes) to yield the title compound as a yellow oil.

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