Реакция #68124

Уравнение реакции

ethyl 4-(3-(7-methoxy-2-oxo-1,2-dihydroquinolin-1-yl)propyl)-1-(2-phenoxyethyl)piperidine-4-carboxylate

sodium hydroxide

→

4-(3-(7-methoxy-2-oxo-1,2-dihydroquinolin-1-yl)propyl)-1-(2-phenoxyethyl)piperidine-4-carboxylic acid

Выход 76.9%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added at room temperature
2. 2
   Температураrefluxed
3. 3
   Температураwith heating for 4.5 hours
4. 4
   Другоеthe solvent was removed under reduced pressure, water
5. 5
   workup.ADDITIONwas added
6. 6
   ФильтрацияThe resulting solid was filtered

Методика

To 1.5 mL of an ethanol solution containing 0.12 g of ethyl 4-(3-(7-methoxy-2-oxo-1,2-dihydroquinolin-1-yl)propyl)-1-(2-phenoxyethyl)piperidine-4-carboxylate, 0.7 mL of 20% aqueous sodium hydroxide solution was added at room temperature and refluxed with heating for 4.5 hours. After the reaction mixture was cooled to the room temperature, the solvent was removed under reduced pressure, water was added, adjusted to pH 6.5 with 6.0 mol/L hydrochloric acid. The resulting solid was filtered to give 87 mg of 4-(3-(7-methoxy-2-oxo-1,2-dihydroquinolin-1-yl)propyl)-1-(2-phenoxyethyl)piperidine-4-carboxylic acid as a pale yellow solid.

Источник