Реакция #67989

Уравнение реакции

methyl 3-oxo-3-(1,3-thiazol-2-yl)propionate

m-anisidine

→

N-(3-methoxyphenyl)-3-oxo-3-(1,3-thiazol-2-yl)propaneamide

Растворители

xylene

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Температураunder reflux
3. 3
   Температураby heating
4. 4
   ДругоеThe solvent was removed under reduced pressure, and water and ethyl acetate
5. 5
   workup.ADDITIONwere added
6. 6
   ДругоеThe organic layer was separated
7. 7
   Экстракцияthe aqueous layer was extracted with ethyl acetate
8. 8
   Промывкаthe resultant solution was washed with an aqueous saturated sodium chloride solution
9. 9
   Сушкаdried over anhydrous magnesium sulfate
10. 10
    Другоеthe solvent was removed under reduced pressure

Методика

To 30 mL of a xylene solution containing 2.3 g of methyl 3-oxo-3-(1,3-thiazol-2-yl)propionate, 1.4 mL of m-anisidine was added. The reaction mixture was stirred for 6 hours under reflux by heating. The solvent was removed under reduced pressure, and water and ethyl acetate were added thereto. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined, the resultant solution was washed with an aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 3.3 g of a brown oily substance, N-(3-methoxyphenyl)-3-oxo-3-(1,3-thiazol-2-yl)propaneamide.

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