Реакция #67962

Уравнение реакции

1-tert-butyl 3-ethyl 4-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-1,3-dicarboxylate

hydrogen chloride ethanol

water

→

ethyl 1-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-2-carboxylate

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Другоеthe solvent was removed under reduced pressure
2. 2
   ДругоеThe residue thus obtained
3. 3
   ДругоеThe aqueous layer was separated
4. 4
   workup.ADDITIONethyl acetate was added
5. 5
   ДругоеThe organic layer was separated
6. 6
   Сушкаdried over potassium carbonate
7. 7
   Другоеthe solvent was removed under reduced pressure

Методика

To 0.60 g of 1-tert-butyl 3-ethyl 4-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-1,3-dicarboxylate, 12 mL of 10 mol/L hydrogen chloride/ethanol was added, and the mixture was stirred for 2 hours, and then the solvent was removed under reduced pressure. The residue thus obtained was added with water and ethyl acetate. The aqueous layer was separated, ethyl acetate was added thereto, and the resultant solution was adjusted to pH 14 with a 5 mol/L aqueous sodium hydroxide solution. The organic layer was separated and dried over potassium carbonate, and the solvent was removed under reduced pressure to obtain 0.34 g of a brown oily substance, ethyl 1-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl)piperazine-2-carboxylate.

Источник