Реакция #67790

Уравнение реакции

ammonium chloride

methyl 2-bromo-5-fluoroisonicotinate

tetrahydrofuran

trimethylaluminum

→

Methyl 5-fluoro-2-methylisonicotinate

Растворители

EtOAc Hexane

EtOAc

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was refluxed for 4 h

Методика

To a solution of methyl 2-bromo-5-fluoroisonicotinate (1.0 g, 4.27 mmol) in tetrahydrofuran (25 ml) tetrakis(triphenylphosphine)palladium (495.0 mg, 0.43 mmol) was added. The mixture was stirred for 10 min, and then trimethylaluminum (5.13 ml, 1.00 M in heptane, 5.13 mmol) was added. The mixture was refluxed for 4 h, and the reaction was monitored by TLC (10% EtOAc-Hexane). Then, the reaction was diluted with EtOAc (75 ml) and a few drops of saturated. ammonium chloride were added.

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