Реакция #675974

Уравнение реакции

2-(2-(2-(4,5-dichloro-2-iodophenoxy)pyridin-4-yloxy)ethyl)isoindoline-1,3-dione

→

desired product

Выход 38.0%

2-(2-(4,5-Dichloro-2-iodophenoxy)pyridin-4-yloxy)ethanamine

Выход 38.0%

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Температураat reflux for 1 h
2. 2
   Концентрированиеconcentrated in vacuo
3. 3
   ДругоеThe precipitate was removed by filtration
4. 4
   Концентрированиеthe filtrate was concentrated in vacuo
5. 5
   ДругоеThe residue was purified by flash column chromatography on silica gel (DCM/MeOH=10:1)

Методика

The mixture of 2-(2-(2-(4,5-dichloro-2-iodophenoxy)pyridin-4-yloxy)ethyl)isoindoline-1,3-dione (120 mg, 0.22 mmol), N2H4.H2O (106 mg, 1.80 mmol) and EtOH (5 mL) was stirred at reflux for 1 h. The mixture was allowed to cool to room temperature and then concentrated in vacuo. The residue was slurried in DCM (5 mL) and MeOH (1 mL). The precipitate was removed by filtration, and the filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (DCM/MeOH=10:1) to afford the desired product (35 mg, 38% yield).

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