Реакция #675791

ord-d238c02667054af9a6c0bd9907964fd2

Уравнение реакции

Clc1c(-c2ccccc2)nnc2[nH]nc(-c3ccccc3)c12
4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine
CC(=O)CCO
4-hydroxybutan-2-one
→
CC(=O)CCn1nc(-c2ccccc2)c2c(Cl)c(-c3ccccc3)nnc21
4-(4-chloro-3,5-diphenyl-pyrazolo[3,4-c]pyridazin-1-yl)butan-2-one

Реактанты

Clc1c(-c2ccccc2)nnc2[nH]nc(-c3ccccc3)c12
4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine
CC(=O)CCO
4-hydroxybutan-2-one

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    Другоеfor the Mitsunobu reaction

Методика

Compound IIm was synthesized from 4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine and 4-hydroxybutan-2-one following the general procedure for the Mitsunobu reaction as described above.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US09227976B2uspto-grants-2016_01