Реакция #67487

Уравнение реакции

dimethylaspartic acid

sulfuric acid

→

N,N-dimethylaspartic acid sulfate

Выход 95.4%

Растворители

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.WAITa reaction was conducted for 2 hours
3. 3
   КонцентрированиеThe reaction solution was concentrated
4. 4
   Другоеazeotroped with 100 ml of toluene
5. 5
   Другоеto further remove the water
6. 6
   ДругоеAfterwards, the product was dried under high vacuum, and ground

Методика

10 g of dimethylaspartic acid was placed in a 250 ml round-bottom flask, and 40 ml of water was added and stirred for 30 minutes. Then, 7.36 g of concentrated sulfuric acid (concentration: 98%) was slowly added to the flask. After the addition, a reaction was conducted for 2 hours. The reaction solution was concentrated, and azeotroped with 100 ml of toluene to further remove the water. Afterwards, the product was dried under high vacuum, and ground by using a spatula to obtain 15.34 g of N,N-dimethylaspartic acid sulfate as tawny oil (Yield: 95.33%).

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