Реакция #674330

ord-3e2e7ef0c7134ccfba4a21ef0af0a8ef

Уравнение реакции

NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCCCC3)n2)c1
B1
NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCCCC3)n2)c1
3-[(4-(Piperidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethane sulfonamide
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
OCC1CNCCN1
rac-2-(hydroxymethyl)piperazine
→
NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCNCC3CO)n2)c1
rac-3-[(4-(2-(Hydroxymethyl)piperazin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Реактанты

NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCCCC3)n2)c1
B1
NS(=O)(=O)Cc1cccc(Nc2ncnc(N3CCCCC3)n2)c1
3-[(4-(Piperidin-1-yl)-1,3,5-triazin-2-yl)amino]benzenemethane sulfonamide
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
OCC1CNCCN1
rac-2-(hydroxymethyl)piperazine

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеB13 was prepared

Методика

B13 was prepared following the procedure reported for B1 using A1 and rac-2-(hydroxymethyl)piperazine. MS (ES) C15H21N7O3S requires: 379. found: 380 (M+H)+.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US09226929B2uspto-grants-2016_01