Реакция #674315

Уравнение реакции

methylphenidate hydrochloride

Ammonium hydroxide

→

oil

Выход 98.0%

d-Methylphenidate

Выход 98.0%

Растворители

water

Условия реакции

Обработка

1. 1
   Другоеformed
2. 2
   ЭкстракцияThe product was extracted with three 100 mL portions of ethyl acetate
3. 3
   Сушкаthe combined organic layers were dried over sodium sulfate
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated
6. 6
   Другоеat 40° C.

Методика

To a 200 mL beaker was charged 10.0 g (37.1 mmol) racemic-methylphenidate hydrochloride and 135 mL water. Ammonium hydroxide (3.40 g; 96.8 mmol) was then added to bring the pH to approximately 9 upon which an oily semi-solid formed. The product was extracted with three 100 mL portions of ethyl acetate, the combined organic layers were dried over sodium sulfate, filtered and concentrated under reduce pressure at 40° C. to provide 8.5 g of a clear, colorless viscous oil (98% yield). The free base was characterized by FTIR and found to be consistent with the anticipated structure

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