Реакция #674314

Уравнение реакции

methylphenidate hydrochloride

ammonium hydroxide

→

oil

Выход 95.0%

Methylphenidate

Выход 95.0%

Растворители

water

Условия реакции

Обработка

1. 1
   Другоеformed
2. 2
   ЭкстракцияThe product was extracted with three 100 mL portions of ethyl acetate
3. 3
   Сушкаthe combined organic layers dried over sodium sulfate
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated under reduced pressure at about 40° C.

Методика

To a 200 mL beaker was charged 10.0 g (37.1 mmol) racemic-methylphenidate hydrochloride and 135 mL water. About 3.39 g (96.8 mmol) ammonium hydroxide was then added to bring the pH to approximately 9 upon which an oily semi-solid formed. The product was extracted with three 100 mL portions of ethyl acetate, the combined organic layers dried over sodium sulfate, filtered and concentrated under reduced pressure at about 40° C. to provide 8.2 g of a clear, colorless viscous oil (95% yield). The IR spectrum of the oil was consistent with the intended product.

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