Реакция #67297

Уравнение реакции

[(2S)-8-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl]methanol

toluenesulfonyl chloride

DCM

→

title compound

[(2R)-8-FLUORO-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL 4-METHYLBENZENESULFONATE

Условия реакции

Обработка

1. 1
   ДругоеPreparation

Методика

Preparation according to Preparation 22 using [(2S)-8-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl]methanol (7.05 g, 38.0 mmol), toluenesulfonyl chloride (10.9 g, 57 mmol), TEA (8.0 ml, 57 mmol) and 4-DMAP (4.7 g, 38.0 mmol) in DCM (75 ml), stirred for 1.5 h. Flash column chromatography yielded 11.9 g of the title compound. MS m/z (rel. intensity, 70 eV) 184 (90), 153 (43), 139 (29), 128 (bp), 57 (25).

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