Реакция #67221

ord-bc867fc86a7d45e49cebcdbbb9542f29

Уравнение реакции

Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(Cl)cc(S(C)(=O)=O)cc3O2)cc1
[(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
CCCNCCC
N-propylpropan-1-amine
→
CCCN(CCC)C[C@H]1COc2c(Cl)cc(S(C)(=O)=O)cc2O1
N-{[(2S)-5-CHLORO-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}-N-PROPYLPROPAN-1-AMINE

Реактанты

Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(Cl)cc(S(C)(=O)=O)cc3O2)cc1
[(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
—
( 7 )
—
( 6 )
—
( 9 )
—
( 4 )
CCCNCCC
N-propylpropan-1-amine

Реагенты

Нет

Растворители

CC#N
ACN

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеPreparation

Методика

Preparation according to Example 57 using [(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.027 g, 0.062 mmol), N-propylpropan-1-amine (0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 361 (M+, 0.2), 332 (6), 115 (9), 114 (bp), 86 (7), 72 (4).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08524766B2uspto-grants-2013_09