Реакция #67154

Уравнение реакции

N-(2-chloro-5-{4-(5-methyl-1,3,4-oxadiazol-2-yl)-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide

sodium hydroxide

→

title compound

Выход 85.2%

N-{2-Chloro-5-[4-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide

Выход 85.2%

Растворители

isopropanol

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed
2. 2
   Другоеthe residue partitioned between water (5 ml) and dichloromethane (5 ml)
3. 3
   Экстракцияextracted with dichloromethane (20 ml)
4. 4
   КонцентрированиеThe organic layer was concentrated

Методика

N-(2-chloro-5-{4-(5-methyl-1,3,4-oxadiazol-2-yl)-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide (16 mg, 0.029 mmol) and 2M sodium hydroxide (1 ml, 2.0 mmol) were placed in isopropanol (5 ml) and the mixture stirred at room temperature overnight. The solvent was removed and the residue partitioned between water (5 ml) and dichloromethane (5 ml). The aqueous was acidified to ˜pH 1 with 2M hydrogen chloride, then extracted with dichloromethane (20 ml). The organic layer was concentrated to give the title compound as a white solid (10 mg).

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