Реакция #6702

Уравнение реакции

water

4-Bromobenzaldehyde

p-toluenesulfonic acid monohydrate

ethylene glycol

→

2-(4-bromophenyl)-1,3-dioxolane

Растворители

ethyl acetate

benzene

Условия реакции

Обработка

1. 1
   ПромывкаThis solution was washed twice with aqueous bicarbonate
2. 2
   Сушкаdried over magnesium sulfate
3. 3
   Концентрированиеconcentrated under reduced pressure
4. 4
   ДругоеA colorless oil was recovered

Методика

4-Bromobenzaldehyde (3 g, 0.0162 mol) in benzene (60 mL) was treated with p-toluenesulfonic acid monohydrate (0.15 g, 0.79 mmol) and ethylene glycol (5 mL, 0.0896 mol). The reaction was refluxed under nitrogen with azeotropic removal of water. After 3 hours, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This solution was washed twice with aqueous bicarbonate, dried over magnesium sulfate and concentrated under reduced pressure. A colorless oil was recovered. Yield=2.83 g (92%). TLC (5% ethyl acetate in hexanes) showed clean product, Rf=0.17.

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