Реакция #669799

Уравнение реакции

2-hydroxyacetophenone

butyryl chloride

diethyl ether

→

2-Acetylphenyl butyrate

Растворители

pyridine

Условия реакции

Обработка

1. 1
   Промывкаwashed successively with water and aqueous hydrochloric acid
2. 2
   СушкаThe organic phase is then dried over sodium sulfate
3. 3
   Концентрированиеconcentrated under reduced pressure
4. 4
   Другоеare obtained in oil form

Методика

A mixture of 50 g (367 mmol) of 2-hydroxyacetophenone and 47 g (440 mmol) of butyryl chloride in 100 ml of pyridine is stirred for 30 minutes, then diluted with diethyl ether and washed successively with water and aqueous hydrochloric acid. The organic phase is then dried over sodium sulfate, concentrated under reduced pressure and coevaporated 3 times with toluene. By chromatography of the residue on a silica column using a 0-30% mixture of ethyl acetate in cyclohexane, 72 g of product are obtained in oil form.

Источник